› 4p8l

X-ray diffraction
2.02Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable decaprenylphosphoryl-beta-D-ribose oxidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 480 amino acids
Theoretical weight: 52.26 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

3 bound ligands:
Ligand FAD 2 x FAD
Ligand 36C 2 x 36C
Ligand IMD 1 x IMD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 76.946Å b: 83.149Å c: 80.524Å
α: 90° β: 102.79° γ: 90°
R-values:
R R work R free
0.195 0.193 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

18 review citations

Hit Generation in TB Drug Discovery: From Genome to Granuloma.
Yuan et al. (2018)
17 more