› 4p9l

X-ray diffraction
1.44Å resolution

Crystal Structure of mouse Ryanodine Receptor 2 SPRY2 Domain (1080-1253) disease mutant A1107M

Released:
DOI: 10.2210/pdb4p9l/pdb
PDB entry 4p9l coloured by chain, front view.
PDB entry 4p9l coloured by chain, side view.
PDB entry 4p9l coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.
Lau K, Van Petegem F
Nat Commun 5 5397 (2014)
PMID: 25370123

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-123214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 177 amino acids
Theoretical weight: 19.95 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: E9Q401 (Residues: 1080-1253; Coverage: 4%)
Gene name: Ryr2
Sequence domains: SPRY domain
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Unit cell:
a: 36.738Å b: 66.989Å c: 67.232Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.151 0.184
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

Ryanodine Receptor Structure and Function in Health and Disease.
Santulli et al. (2018)
9 more

3 mentions without citation

Single-Particle Cryo-EM of the Ryanodine Receptor Channel in an Aqueous Environment.
Baker et al. (2015)
2 more