› 4p9m

X-ray diffraction
2.13Å resolution

Crystal structure of 8ANC195 Fab

Released:
DOI: 10.2210/pdb4p9m/pdb
PDB entry 4p9m coloured by chain, front view.
PDB entry 4p9m coloured by chain, side view.
PDB entry 4p9m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike.
Scharf L, Scheid JF, Lee JH, West AP, Chen C, Gao H, Gnanapragasam PN, Mares R, Seaman MS, Ward AB, Nussenzweig MC, Bjorkman PJ
Cell Rep 7 785-95 (2014)
PMID: 24767986

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230410 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
8ANC195 light chain Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
8ANC195 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 244 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P41212
Unit cell:
a: 66.482Å b: 66.482Å c: 219.034Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.239
Expression system: Homo sapiens

Quick links

Citations

34 review citations

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.
Burton et al. (2016)
33 more

7 mentions without citation

Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies.
Zhang et al. (2016)
6 more