› 4pb1

X-ray diffraction
2.8Å resolution

Structure of vcCNT-7C8C bound to ribavirin

Released:
DOI: 10.2210/pdb4pb1/pdb
PDB entry 4pb1 coloured by chain, front view.
PDB entry 4pb1 coloured by chain, side view.
PDB entry 4pb1 coloured by chain, top view.
Source organism: Vibrio cholerae O1 biovar El Tor str. N16961
Primary publication:
Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Johnson ZL, Lee JH, Lee K, Lee M, Kwon DY, Hong J, Lee SY
Elife 3 e03604 (2014)
PMID: 25082345

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside permease Chain: A
Molecule details ›
Chain: A
Length: 424 amino acids
Theoretical weight: 44.15 KDa
Source organism: Vibrio cholerae O1 biovar El Tor str. N16961
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9KPL5 (Residues: 1-418; Coverage: 100%)
Gene name: VC_2352
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand RBV 1 x RBV
Ligand NA 1 x NA
Ligand DMU 1 x DMU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P63
Unit cell:
a: 119.749Å b: 119.749Å c: 83.638Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.222 0.259
Expression system: Escherichia coli

Quick links

Citations

7 review citations

SLC transporters as therapeutic targets: emerging opportunities.
Lin et al. (2015)
6 more

4 mentions without citation

Elevator-type mechanisms of membrane transport.
Garaeva et al. (2020)
3 more