› 4pbp

X-ray diffraction
1.65Å resolution

crystal structure of zebrafish short-chain pentraxin protein

Released:
DOI: 10.2210/pdb4pbp/pdb
PDB entry 4pbp coloured by chain, front view.
PDB entry 4pbp coloured by chain, side view.
PDB entry 4pbp coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces.
Chen R, Qi J, Yuan H, Wu Y, Hu W, Xia C
J Struct Biol 189 259-68 (2015)
PMID: 25592778

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170966 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-reactive protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 210 amino acids
Theoretical weight: 23.97 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0IIP8 (Residues: 19-225; Coverage: 100%)
Gene name: crp
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 6 x CA
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P65
Unit cell:
a: 153.623Å b: 153.623Å c: 62.33Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.153 0.171
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Regulation of C-reactive protein conformation in inflammation.
Yao et al. (2019)
5 other articles

1 mention without citation

Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms.
Bello-Perez et al. (2019)