› 4pir

X-ray diffraction
3.5Å resolution

X-ray structure of the mouse serotonin 5-HT3 receptor

Released:
DOI: 10.2210/pdb4pir/pdb
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PDB entry 4pir coloured by chain, front view.
PDB entry 4pir coloured by chain, side view.
PDB entry 4pir coloured by chain, top view.
Source organisms:
Primary publication:
X-ray structure of the mouse serotonin 5-HT3 receptor.
Hassaine G, Deluz C, Grasso L, Wyss R, Tol MB, Hovius R, Graff A, Stahlberg H, Tomizaki T, Desmyter A, Moreau C, Li XD, Poitevin F, Vogel H, Nury H
Nature 512 276-81 (2014)
PMID: 25119048

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210873 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
5-hydroxytryptamine receptor 3A Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 456 amino acids
Theoretical weight: 52.61 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P23979 (Residues: 28-31, 33-303, 305-489; Coverage: 97%)
  • Best match: P23979-2 (Residues: 28-31, 33-303, 305-483)
Gene names: 5ht3, Htr3, Htr3a
Sequence domains:
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain
VHH15 Chains: F, G, H, I, J
Molecule details ›
Chains: F, G, H, I, J
Length: 124 amino acids
Theoretical weight: 13.46 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
3 bound ligands:
Ligand CL 5 x CL
Ligand SO4 3 x SO4
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 121.542Å b: 187.087Å c: 240.554Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.257
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

52 review citations

Nicotinic ACh receptors as therapeutic targets in CNS disorders.
Dineley et al. (2015)
51 more

53 mentions without citation

Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.
Burgos et al. (2016)
52 more

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