PDB 4pjo structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

RNA binding

Biological process:

spliceosomal snRNP assembly

Cellular component:

U1 snRNP

Sequence domains:

10 more domains

Structure analysis Details

Assembly composition:

hetero undecamer (preferred)

PDBe Complex ID:

PDB-CPX-140244 (preferred)

Entry contents:

9 distinct polypeptide molecules
2 distinct RNA molecules

Macromolecules (11 distinct):

Small nuclear ribonucleoprotein Sm D3 Chains: A, O, a, o

Molecule details ›

Chains: A, O, a, o
Length: 126 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P62318 (Residues: 1-126; Coverage: 100%)

Gene name: SNRPD3
Sequence domains: LSM domain
Structure domains: SH3 type barrels.

Small nuclear ribonucleoprotein-associated proteins B and B' Chains: B, P, b, p

Molecule details ›

Chains: B, P, b, p
Length: 95 amino acids
Theoretical weight: 10.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P14678 (Residues: 1-95; Coverage: 40%)

Gene names: COD, SNRPB, SNRPB1
Sequence domains: LSM domain
Structure domains: SH3 type barrels.

Small nuclear ribonucleoprotein Sm D1 Chains: C, Q, c, q

Molecule details ›

Chains: C, Q, c, q
Length: 91 amino acids
Theoretical weight: 10.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P62314 (Residues: 2-85; Coverage: 71%)

Gene name: SNRPD1
Sequence domains: LSM domain
Structure domains: SH3 type barrels.

Small nuclear ribonucleoprotein Sm D2 Chains: D, R, d, r

Molecule details ›

Chains: D, R, d, r
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P62316 (Residues: 1-118; Coverage: 100%)

Gene names: SNRPD1, SNRPD2
Sequence domains: LSM domain
Structure domains: SH3 type barrels.

Small nuclear ribonucleoprotein E Chains: E, S, e, s

Molecule details ›

Chains: E, S, e, s
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P62304 (Residues: 1-92; Coverage: 100%)

Gene name: SNRPE
Sequence domains: LSM domain
Structure domains: SH3 type barrels.

Small nuclear ribonucleoprotein F Chains: F, T, f, t

Molecule details ›

Chains: F, T, f, t
Length: 75 amino acids
Theoretical weight: 8.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P62306 (Residues: 1-75; Coverage: 87%)

Gene names: PBSCF, SNRPF
Sequence domains: LSM domain
Structure domains: SH3 type barrels.

Small nuclear ribonucleoprotein G Chains: G, U, g, u

Molecule details ›

Chains: G, U, g, u
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P62308 (Residues: 1-76; Coverage: 100%)

Gene names: PBSCG, SNRPG
Sequence domains: LSM domain
Structure domains: SH3 type barrels.

U1 small nuclear ribonucleoprotein 70 kDa Chains: K, N, k, n

Molecule details ›

Chains: K, N, k, n
Length: 60 amino acids
Theoretical weight: 6.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P08621 (Residues: 2-60; Coverage: 14%)

Gene names: RNPU1Z, RPU1, SNRNP70, SNRP70, U1AP1
Sequence domains: U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

U1 small nuclear ribonucleoprotein C Chains: L, M, l, m

Molecule details ›

Chains: L, M, l, m
Length: 61 amino acids
Theoretical weight: 7.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli B
UniProt: