› 4pl5

X-ray diffraction
3.4Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190166 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase/endoribonuclease IRE1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 435 amino acids
Theoretical weight: 50.33 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9EQY0 (Residues: 550-977; Coverage: 45%)
Gene names: Ern1, Ire1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand ADP 4 x ADP
Ligand MG 4 x MG
Ligand 31L 1 x 31L
Ligand PEU 1 x PEU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2
Unit cell:
a: 319.22Å b: 63.03Å c: 140.78Å
α: 90° β: 99.49° γ: 90°
R-values:
R R work R free
0.225 0.222 0.285
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.
Almanza et al. (2019)
34 more

6 mentions without citation

HEPN RNases - an emerging class of functionally distinct RNA processing and degradation enzymes.
Pillon et al. (2021)
5 more