› 4pni

X-ray diffraction
1.85Å resolution

Bovine G protein-coupled receptor kinase 1 in complex with GSK2163632A

Released:
DOI: 10.2210/pdb4pni/pdb
PDB entry 4pni coloured by chain, front view.
PDB entry 4pni coloured by chain, side view.
PDB entry 4pni coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors.
Homan KT, Larimore KM, Elkins JM, Szklarz M, Knapp S, Tesmer JJ
ACS Chem Biol 10 310-9 (2015)
PMID: 25238254

Function and Biology Details

Reaction catalysed: 
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rhodopsin kinase GRK1 Chain: A
Molecule details ›
Chain: A
Length: 561 amino acids
Theoretical weight: 63.01 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P28327 (Residues: 1-561; Coverage: 100%)
Gene names: GRK1, RHOK
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand KQQ 1 x KQQ
Ligand CL 6 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Unit cell:
a: 45.485Å b: 66.566Å c: 205.499Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.23
Expression system: Trichoplusia ni

Quick links

Citations

8 review citations

The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.
Peterson et al. (2017)
7 more

5 mentions without citation

Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors.
Homan et al. (2015)
4 more