› 4pqo

X-ray diffraction
2.55Å resolution

Structure of the human SNX14 PX domain in space group I41

Released:
DOI: 10.2210/pdb4pqo/pdb
PDB entry 4pqo coloured by chain, front view.
PDB entry 4pqo coloured by chain, side view.
PDB entry 4pqo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
Mas C, Norwood SJ, Bugarcic A, Kinna G, Leneva N, Kovtun O, Ghai R, Ona Yanez LE, Davis JL, Teasdale RD, Collins BM
J Biol Chem 289 28554-68 (2014)
PMID: 25148684

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195291 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-14 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 15.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5W7 (Residues: 561-686; Coverage: 13%)
Gene name: SNX14
Sequence domains: PX domain
Structure domains: Phox-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: I41
Unit cell:
a: 86.84Å b: 86.84Å c: 74.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.183 0.209
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism.
Ebrahimi-Fakhari et al. (2016)
7 more

4 mentions without citation

Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein.
Henne et al. (2015)
3 more