› 4pqp

X-ray diffraction
3Å resolution

Crystal structure of human SNX14 PX domain in space group P43212

Released:
DOI: 10.2210/pdb4pqp/pdb
PDB entry 4pqp coloured by chain, front view.
PDB entry 4pqp coloured by chain, side view.
PDB entry 4pqp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
Mas C, Norwood SJ, Bugarcic A, Kinna G, Leneva N, Kovtun O, Ghai R, Ona Yanez LE, Davis JL, Teasdale RD, Collins BM
J Biol Chem 289 28554-68 (2014)
PMID: 25148684

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195291 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-14 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 128 amino acids
Theoretical weight: 15.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5W7 (Residues: 561-686; Coverage: 13%)
Gene name: SNX14
Sequence domains: PX domain
Structure domains: Phox-like domain

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P43212
Unit cell:
a: 121.67Å b: 121.67Å c: 82.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.286
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism.
Ebrahimi-Fakhari et al. (2016)
7 more

2 mentions without citation

Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
Mas et al. (2014)
1 more