› 4pxz

X-ray diffraction
2.5Å resolution

Crystal structure of P2Y12 receptor in complex with 2MeSADP

Released:
DOI: 10.2210/pdb4pxz/pdb
Model geometry
Fit model/data
PDB entry 4pxz coloured by chain, front view.
PDB entry 4pxz coloured by chain, side view.
PDB entry 4pxz coloured by chain, top view.
Source organisms:
Primary publication:
Agonist-bound structure of the human P2Y12 receptor.
Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q
OpenAccess logo Nature 509 119-22 (2014)
PMID: 24784220

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2Y purinoceptor 12; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 466 amino acids
Theoretical weight: 53.25 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9H244 (Residues: 2-223, 224-342; Coverage: 100%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: HORK3, P2RY12, cybC
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand 6AD 1 x 6AD
Ligand CLR 1 x CLR
Ligand OLC 3 x OLC
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL41XU, APS BEAMLINE 23-ID-D
Spacegroup: C2221
Unit cell:
a: 65.11Å b: 104.17Å c: 169.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.23
Expression system: Spodoptera frugiperda

Quick links

Citations

49 review citations

Nucleotide signalling during inflammation.
Idzko et al. (2014)
48 more

79 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
78 more