› 4pzg

X-ray diffraction
2.8Å resolution

Crystal structure of human sorting nexin 10 (SNX10)

Released:
DOI: 10.2210/pdb4pzg/pdb
PDB entry 4pzg coloured by chain, front view.
PDB entry 4pzg coloured by chain, side view.
PDB entry 4pzg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.
Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J
Proteins 82 3483-9 (2014)
PMID: 25212774

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195297 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5X0 (Residues: 1-201; Coverage: 100%)
Gene name: SNX10
Sequence domains: PX domain
Structure domains: Phox-like domain

Ligands and Environments

2 bound ligands:
Ligand NO3 11 x NO3
Ligand PE5 7 x PE5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3221
Unit cell:
a: 205.859Å b: 205.859Å c: 42.33Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.194 0.237
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats.
Cervantes-Anaya et al. (2017)
4 more

4 mentions without citation

Druggability of Coronary Artery Disease Risk Loci.
Tragante et al. (2018)
3 more