› 4q2p

X-ray diffraction
2.05Å resolution

NHERF3 PDZ2 in Complex with a Phage-Derived Peptide

Released:
DOI: 10.2210/pdb4q2p/pdb
PDB entry 4q2p coloured by chain, front view.
PDB entry 4q2p coloured by chain, side view.
PDB entry 4q2p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A structural portrait of the PDZ domain family.
Ernst A, Appleton BA, Ivarsson Y, Zhang Y, Gfeller D, Wiesmann C, Sidhu SS
J Mol Biol 426 3509-19 (2014)
PMID: 25158098

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178300 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 99 amino acids
Theoretical weight: 10.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5T2W1 (Residues: 132-215; Coverage: 16%)
Gene names: CAP70, NHERF3, PDZD1, PDZK1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:
Ligand TRS 1 x TRS
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: R3
Unit cell:
a: 153.31Å b: 153.31Å c: 34.635Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.188 0.252
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Structural Features of Tight-Junction Proteins.
Heinemann et al. (2019)
9 more