4q6y

X-ray diffraction
3Å resolution

Crystal structure of a chemoenzymatic glycoengineered disialylated Fc (di-sFc)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 221 amino acids
Theoretical weight: 24.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 109-328; Coverage: 55%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, SIA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21
Unit cell:
a: 52.73Å b: 154.22Å c: 66.12Å
α: 90° β: 110.78° γ: 90°
R-values:
R R work R free
0.26 0.26 0.28
Expression system: Homo sapiens