› 4q8d

X-ray diffraction
1.75Å resolution

Crystal structure of a macrocyclic beta-sheet peptide containing two beta-strands from amyloid beta residues 15-23

Released:
DOI: 10.2210/pdb4q8d/pdb
PDB entry 4q8d coloured by chain, front view.
PDB entry 4q8d coloured by chain, side view.
PDB entry 4q8d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A fibril-like assembly of oligomers of a peptide derived from β-amyloid.
Pham JD, Spencer RK, Chen KH, Nowick JS
J Am Chem Soc 136 12682-90 (2014)
PMID: 25068693

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-165079 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
macrocyclic beta-sheet peptide incorporating residues amyloid beta 15-23 Chains: A, B
Molecule details ›
Chains: A, B
Length: 18 amino acids
Theoretical weight: 2.4 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MPD 2 x MPD
2 modified residues:
Ligand ORN 4 x ORN
Ligand PHI 2 x PHI

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 32.174Å b: 62.852Å c: 20.094Å
α: 90° β: 89.98° γ: 90°
R-values:
R R work R free
0.186 0.179 0.22
Expression system: Not provided

Quick links

Citations

3 review citations

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
2 more