› 4qc1

X-ray diffraction
1.99Å resolution

Crystal structure of human BAZ2B bromodomain in complex with an acetylated histone 3 peptide (H3K14ac)

Released:
DOI: 10.2210/pdb4qc1/pdb
PDB entry 4qc1 coloured by chain, front view.
PDB entry 4qc1 coloured by chain, side view.
PDB entry 4qc1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Tallant C, Valentini E, Fedorov O, Overvoorde L, Ferguson FM, Filippakopoulos P, Svergun DI, Knapp S, Ciulli A
Structure 23 80-92 (2015)
PMID: 25533489

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165090 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain adjacent to zinc finger domain protein 2B Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 12.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF8 (Residues: 2062-2166; Coverage: 5%)
Gene names: BAZ2B, KIAA1476
Sequence domains: Bromodomain
Structure domains: Bromodomain-like
acetylated histone 3 peptide (H3K14ac) Chains: D, E
Molecule details ›
Chains: D, E
Length: 11 amino acids
Theoretical weight: 1.2 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand SO4 1 x SO4
1 modified residue:
Ligand ALY 2 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 29.724Å b: 67.012Å c: 136.055Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.256
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

16 review citations

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes.
Clapier et al. (2017)
15 more

4 mentions without citation

At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.
Hagan et al. (2009)
3 more