› 4qci

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208347 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
anti-PDGF-BB antibody - Light Chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 209 amino acids
Theoretical weight: 22.38 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
anti-PDGF-BB antibody - Heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 223 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Platelet-derived growth factor subunit B Chains: C, D
Molecule details ›
Chains: C, D
Length: 110 amino acids
Theoretical weight: 12.44 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01127 (Residues: 82-190; Coverage: 49%)
Gene names: PDGF2, PDGFB, SIS
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 90.15Å b: 68.47Å c: 95.25Å
α: 90° β: 97.56° γ: 90°
R-values:
R R work R free
0.213 0.211 0.248
Expression system: Cricetulus griseus

Quick links

Citations

4 review citations

ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis.
Foglia et al. (2019)
3 more

5 mentions without citation

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design.
Adolf-Bryfogle et al. (2018)
4 more