› 4qhu

X-ray diffraction
2.2Å resolution

Crystal Structure of IL-17A/Fab6785 complex

Released:
DOI: 10.2210/pdb4qhu/pdb
PDB entry 4qhu coloured by chain, front view.
PDB entry 4qhu coloured by chain, side view.
PDB entry 4qhu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Luo J, Gilliland GL, Malia T, Obmolova G, Teplyakov A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212054 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab6785 light chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 214 amino acids
Theoretical weight: 22.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fab6785 heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 224 amino acids
Theoretical weight: 23.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Interleukin-17A Chains: C, D
Molecule details ›
Chains: C, D
Length: 132 amino acids
Theoretical weight: 15.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16552 (Residues: 24-154; Coverage: 99%)
Gene names: CTLA8, IL17, IL17A
Sequence domains: Interleukin-17
Structure domains: Cystine-knot cytokines

Ligands and Environments

3 bound ligands:
Ligand GOL 5 x GOL
Ligand CL 1 x CL
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 73.21Å b: 64Å c: 145.6Å
α: 90° β: 95.64° γ: 90°
R-values:
R R work R free
0.173 0.171 0.216
Expression systems:
  • Homo sapiens
  • Escherichia coli

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