› 4qkc

X-ray diffraction
1.1Å resolution

Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under cryo diffraction conditions

Released:
DOI: 10.2210/pdb4qkc/pdb
PDB entry 4qkc coloured by chain, front view.
PDB entry 4qkc coloured by chain, side view.
PDB entry 4qkc coloured by chain, top view.
Source organism: Influenza A virus (A/udorn/1972(H3N2))
Primary publication:
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.
Thomaston JL, Alfonso-Prieto M, Woldeyes RA, Fraser JS, Klein ML, Fiorin G, DeGrado WF
Proc Natl Acad Sci U S A 112 14260-5 (2015)
PMID: 26578770

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 2.75 KDa
Source organism: Influenza A virus (A/udorn/1972(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P0DOF5 (Residues: 22-46; Coverage: 26%)
Gene name: M

Ligands and Environments

4 bound ligands:
Ligand CA 2 x CA
Ligand CL 1 x CL
Ligand EDO 1 x EDO
Ligand OLB 2 x OLB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: I4
Unit cell:
a: 29.31Å b: 29.31Å c: 67.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.11 0.108 0.128
Expression system: Not provided

Quick links

Citations

9 review citations

Structure and Dynamics of Membrane Proteins from Solid-State NMR.
Mandala et al. (2018)
8 more

2 mentions without citation

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.
Thomaston et al. (2015)
1 more