› 4qm1

X-ray diffraction
2.8Å resolution

Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor D67

Released:
DOI: 10.2210/pdb4qm1/pdb
PDB entry 4qm1 coloured by chain, front view.
PDB entry 4qm1 coloured by chain, side view.
PDB entry 4qm1 coloured by chain, top view.
Source organism: Bacillus anthracis
Entry authors: Kim Y, Makowska-Grzyska M, Gu M, Mandapati K, Gollapalli D, Gorla SK, Zhang M, Hedstrom L, Anderson WF, Joachimiak A, CSGID, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 384 amino acids
Theoretical weight: 40.71 KDa
Source organism: Bacillus anthracis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A6L8P2U9 (Residues: 1-91, 221-487; Coverage: 74%)
Gene names: GBAA_0008, guaB
Sequence domains: IMP dehydrogenase / GMP reductase domain
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand IMP 4 x IMP
Ligand 39H 4 x 39H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 83.13Å b: 101.331Å c: 87.267Å
α: 90° β: 109.57° γ: 90°
R-values:
R R work R free
0.195 0.192 0.248
Expression system: Escherichia coli

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