4qn5

X-ray diffraction
1.7Å resolution

Neuraminidase N5 binds LSTa at the second SIA binding site

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173130 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 395 amino acids
Theoretical weight: 43.53 KDa
Source organism: Influenza A virus (A/mallard duck/ALB/60/1976(H12N5))
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q20UH7 (Residues: 79-473; Coverage: 84%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: SIA, GAL
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P4
Unit cell:
a: 112.251Å b: 112.251Å c: 66.756Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.12 0.117 0.176
Expression system: Spodoptera frugiperda