› 4qo3

X-ray diffraction
2.05Å resolution

Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor

Released:
DOI: 10.2210/pdb4qo3/pdb
PDB entry 4qo3 coloured by chain, front view.
PDB entry 4qo3 coloured by chain, side view.
PDB entry 4qo3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Blaber M, Xia X

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:
Ligand FLC 2 x FLC
Ligand IMD 1 x IMD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2221
Unit cell:
a: 75.192Å b: 96.809Å c: 108.191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.158 0.187
Expression system: Escherichia coli BL21(DE3)

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