› 4qqe

X-ray diffraction
1.8Å resolution

Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345

Released:
DOI: 10.2210/pdb4qqe/pdb
PDB entry 4qqe coloured by chain, front view.
PDB entry 4qqe coloured by chain, side view.
PDB entry 4qqe coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Dombrovski L, Wernimont A, Smil D, Getlik M, Senisterra G, Poda G, Al-Awar R, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Schapira M, Vedadi M, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158474 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

4 bound ligands:
Ligand 37F 1 x 37F
Ligand CL 1 x CL
Ligand EDO 3 x EDO
Ligand UNX 7 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21212
Unit cell:
a: 80.896Å b: 85.267Å c: 40.209Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.218
Expression system: Escherichia coli BL21(DE3)

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