› 4qqf

X-ray diffraction
2.67Å resolution

Crystal structure of mitochondrial import inner membrane translocase subunit TIM50

Released:
DOI: 10.2210/pdb4qqf/pdb
PDB entry 4qqf coloured by chain, front view.
PDB entry 4qqf coloured by chain, side view.
PDB entry 4qqf coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
The structure of Tim50(164-361) suggests the mechanism by which Tim50 receives mitochondrial presequences.
Li J, Sha B
Acta Crystallogr F Struct Biol Commun 71 1146-51 (2015)
PMID: 26323300

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial import inner membrane translocase subunit TIM50 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 202 amino acids
Theoretical weight: 23.73 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02776 (Residues: 164-361; Coverage: 42%)
Gene names: TIM50, YPL063W
Sequence domains: NLI interacting factor-like phosphatase
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

1 bound ligand:
Ligand MG 6 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P41212
Unit cell:
a: 164.287Å b: 164.287Å c: 150.532Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.252
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer.
Jackson et al. (2020)
4 other articles

4 mentions without citation

Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase.
Chaudhuri et al. (2021)
3 more