› 4r04

X-ray diffraction
3.26Å resolution

Clostridium difficile Toxin A (TcdA)

Released:
DOI: 10.2210/pdb4r04/pdb
PDB entry 4r04 coloured by chain, front view.
PDB entry 4r04 coloured by chain, side view.
PDB entry 4r04 coloured by chain, top view.
Source organism: Clostridioides difficile
Primary publication:
Glucosyl Transferase Structure
Lacy DB, Spiller BW, Rutherford SA
Nat Microbiol (2016)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147647 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toxin A Chain: A
Molecule details ›
Chain: A
Length: 1838 amino acids
Theoretical weight: 209.84 KDa
Source organism: Clostridioides difficile
Expression system: Not provided
UniProt:
  • Canonical: P16154 (Residues: 1-1832; Coverage: 68%)
Gene names: tcdA, toxA
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2
Unit cell:
a: 303.49Å b: 124.54Å c: 75.95Å
α: 90° β: 97.5° γ: 90°
R-values:
R R work R free
0.222 0.221 0.25
Expression system: Not provided

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