› 4r1c

X-ray diffraction
2Å resolution

Crystal Structure of 3D7 strain Plasmodium falciparum AMA1

Released:
DOI: 10.2210/pdb4r1c/pdb
PDB entry 4r1c coloured by chain, front view.
PDB entry 4r1c coloured by chain, side view.
PDB entry 4r1c coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO.
Lim SS, Yang W, Krishnarjuna B, Kannan Sivaraman K, Chandrashekaran IR, Kass I, MacRaild CA, Devine SM, Debono CO, Anders RF, Scanlon MJ, Scammells PJ, Norton RS, McGowan S
Biochemistry 53 7310-20 (2014)
PMID: 25360546

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181598 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apical membrane antigen 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 38.36 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7KQK5 (Residues: 104-438; Coverage: 56%)
Gene name: PF3D7_1133400
Sequence domains: Apical membrane antigen 1
Structure domains: Hepatocyte Growth Factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 156.529Å b: 54.5Å c: 67.955Å
α: 90° β: 91.42° γ: 90°
R-values:
R R work R free
0.196 0.193 0.247
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Applications of (19)F-NMR in Fragment-Based Drug Discovery.
Norton et al. (2016)
2 more

1 mention without citation

The Search of a Malaria Vaccine: The Time for Modified Immuno-Potentiating Probes.
Lozano et al. (2021)