› 4r4b

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213606 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
FAB 2.2C LIGHT CHAIN Chains: A, C, E, L
Molecule details ›
Chains: A, C, E, L
Length: 210 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
FAB 2.2C HEAVY CHAIN Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 220 amino acids
Theoretical weight: 23.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 36 x SO4
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 195.011Å b: 133.559Å c: 90.774Å
α: 90° β: 91.36° γ: 90°
R-values:
R R work R free
0.168 0.166 0.214
Expression system: Homo sapiens

Quick links

Citations

15 review citations

HIV antibodies for treatment of HIV infection.
Margolis et al. (2017)
14 more

2 mentions without citation

Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.
Acharya et al. (2014)
1 more