› 4rg1

X-ray diffraction
1.86Å resolution

Methyltransferase domain of C9orf114

Released:
DOI: 10.2210/pdb4rg1/pdb
PDB entry 4rg1 coloured by chain, front view.
PDB entry 4rg1 coloured by chain, side view.
PDB entry 4rg1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Walker JR, Li Y, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178296 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative methyltransferase C9orf114 Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 34.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5T280 (Residues: 64-376; Coverage: 83%)
Gene names: C9orf114, SPOUT1
Sequence domains: Putative RNA methyltransferase
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand SAH 2 x SAH
Ligand 15P 4 x 15P
Ligand UNX 2 x UNX
Ligand PGO 1 x PGO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 127.509Å b: 67.816Å c: 85.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 0.208
Expression system: Escherichia coli BL21(DE3)

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