› 4rqm

X-ray diffraction
1.75Å resolution

Crystal structure of the SeMET BICC1 SAM Domain R924E mutant

Released:
DOI: 10.2210/pdb4rqm/pdb
PDB entry 4rqm coloured by chain, front view.
PDB entry 4rqm coloured by chain, side view.
PDB entry 4rqm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.
Rothé B, Leettola CN, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie JU, Constam DB
Structure 26 209-224.e6 (2018)
PMID: 29290488

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190633 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein bicaudal C homolog 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 71 amino acids
Theoretical weight: 8.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H694 (Residues: 870-939; Coverage: 7%)
Gene name: BICC1
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 46.81Å b: 64.43Å c: 70.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Bicaudal-C Post-transcriptional regulator of cell fates and functions.
Dowdle et al. (2022)
2 more

1 mention without citation

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.
Rothé et al. (2018)