› 4rtx

X-ray diffraction
1.32Å resolution

Crystal structure of the Src tyrosine kinase SH3 domain T96G/Q128R mutant

Released:
DOI: 10.2210/pdb4rtx/pdb
PDB entry 4rtx coloured by chain, front view.
PDB entry 4rtx coloured by chain, side view.
PDB entry 4rtx coloured by chain, top view.
Source organism: Gallus gallus
Entry author: Camara-Artigas A

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 61 amino acids
Theoretical weight: 6.89 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 85-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

3 bound ligands:
Ligand NI 4 x NI
Ligand SO4 4 x SO4
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21
Unit cell:
a: 40.091Å b: 49.966Å c: 59.845Å
α: 90° β: 95.51° γ: 90°
R-values:
R R work R free
0.173 0.171 0.207
Expression system: Escherichia coli BL21(DE3)

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