› 4rud

X-ray diffraction
1.95Å resolution

Crystal structure of a three finger toxin

Released:
DOI: 10.2210/pdb4rud/pdb
PDB entry 4rud coloured by chain, front view.
PDB entry 4rud coloured by chain, side view.
PDB entry 4rud coloured by chain, top view.
Source organism: Micrurus fulvius
Primary publication:
Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors.
Foo CS, Jobichen C, Hassan-Puttaswamy V, Dekan Z, Tae HS, Bertrand D, Adams DJ, Alewood PF, Sivaraman J, Nirthanan S, Kini RM
Br J Pharmacol 177 1822-1840 (2020)
PMID: 31877243

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197527 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Three-finger toxin 3b Chains: A, B
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.54 KDa
Source organism: Micrurus fulvius
Expression system: Xenopus laevis
UniProt:
  • Canonical: U3EPL2 (Residues: 22-79; Coverage: 92%)
Structure domains: CD59

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P4212
Unit cell:
a: 58.8Å b: 58.8Å c: 70.567Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.2 0.237
Expression system: Xenopus laevis

Quick links

Citations

1 review citation

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors.
Bekbossynova et al. (2021)
3 other articles

2 mentions without citation

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors.
Foo et al. (2020)
1 more