› 4run

X-ray diffraction
2.6Å resolution

Crystal structure of human odorant binding protein OBPIIa

Released:
DOI: 10.2210/pdb4run/pdb
PDB entry 4run coloured by chain, front view.
PDB entry 4run coloured by chain, side view.
PDB entry 4run coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human odorant binding protein, OBPIIa.
Schiefner A, Freier R, Eichinger A, Skerra A
Proteins 83 1180-4 (2015)
PMID: 25810031

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-192692 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Odorant-binding protein 2a Chains: A, B
Molecule details ›
Chains: A, B
Length: 161 amino acids
Theoretical weight: 18.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NY56 (Residues: 16-170; Coverage: 100%)
Gene name: OBP2A
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand FLC 1 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P41212
Unit cell:
a: 52.949Å b: 52.949Å c: 232.098Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.284
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein- and Peptide-Based Biosensors in Artificial Olfaction.
Barbosa et al. (2018)
1 more

5 mentions without citation

Reverse chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles.
Zhu et al. (2017)
4 more