› 4ryi

X-ray diffraction
3.49Å resolution

Crystal structure of BcTSPO/PK11195 complex

Released:
DOI: 10.2210/pdb4ryi/pdb
PDB entry 4ryi coloured by chain, front view.
PDB entry 4ryi coloured by chain, side view.
PDB entry 4ryi coloured by chain, top view.
Source organism: Bacillus cereus ATCC 14579
Primary publication:
Protein structure. Structure and activity of tryptophan-rich TSPO proteins.
Guo Y, Kalathur RC, Liu Q, Kloss B, Bruni R, Ginter C, Kloppmann E, Rost B, Hendrickson WA
Science 347 551-5 (2015)
PMID: 25635100

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan-rich protein TspO Chains: A, B
Molecule details ›
Chains: A, B
Length: 181 amino acids
Theoretical weight: 21.5 KDa
Source organism: Bacillus cereus ATCC 14579
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q81BL7 (Residues: 1-153; Coverage: 100%)
Gene names: BC_3136, tspO
Sequence domains: TspO/MBR family

Ligands and Environments

1 bound ligand:
Ligand PKA 2 x PKA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21
Unit cell:
a: 56.666Å b: 54.55Å c: 58.56Å
α: 90° β: 105.7° γ: 90°
R-values:
R R work R free
0.24 0.236 0.314
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

29 review citations

Neuroinflammation in Neurodegenerative Disorders-a Review.
Schain et al. (2017)
28 more

12 mentions without citation

VDAC1 and the TSPO: Expression, Interactions, and Associated Functions in Health and Disease States.
Shoshan-Barmatz et al. (2019)
11 more