› 4tnf

X-ray diffraction
1.6Å resolution

Crystal Structure of Human Transthyretin Lys15Trp Mutant

Released:
DOI: 10.2210/pdb4tnf/pdb
PDB entry 4tnf coloured by chain, front view.
PDB entry 4tnf coloured by chain, side view.
PDB entry 4tnf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Saelices L, Cascio D, Sawaya M, Eisenberg DS

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 29-147; Coverage: 94%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand OCS 2 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 42.92Å b: 85.61Å c: 64.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.213
Expression system: Escherichia coli BL21(DE3)

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