› 4u07

X-ray diffraction
2.64Å resolution

ATP bound to eukaryotic FIC domain containing protein

Released:
DOI: 10.2210/pdb4u07/pdb
PDB entry 4u07 coloured by chain, front view.
PDB entry 4u07 coloured by chain, side view.
PDB entry 4u07 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
Bunney TD, Cole AR, Broncel M, Esposito D, Tate EW, Katan M
Structure 22 1831-1843 (2014)
PMID: 25435325

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein adenylyltransferase FICD Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 39.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BVA6 (Residues: 102-445; Coverage: 75%)
Gene names: FICD, HIP13, HYPE, UNQ3041/PRO9857
Sequence domains: Fic/DOC family
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand ATP 2 x ATP
Ligand PG4 2 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 71.254Å b: 76.114Å c: 92.189Å
α: 90° β: 107.28° γ: 90°
R-values:
R R work R free
0.21 0.208 0.258
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Early Events in the Endoplasmic Reticulum Unfolded Protein Response.
Preissler et al. (2019)
3 more

8 mentions without citation

rAMPing Up Stress Signaling: Protein AMPylation in Metazoans.
Truttmann et al. (2017)
7 more