› 4u0z

X-ray diffraction
2.95Å resolution

Eukaryotic Fic Domain containing protein with bound APCPP

Released:
DOI: 10.2210/pdb4u0z/pdb
PDB entry 4u0z coloured by chain, front view.
PDB entry 4u0z coloured by chain, side view.
PDB entry 4u0z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
Bunney TD, Cole AR, Broncel M, Esposito D, Tate EW, Katan M
Structure 22 1831-1843 (2014)
PMID: 25435325

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein adenylyltransferase FICD Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 344 amino acids
Theoretical weight: 39.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BVA6 (Residues: 102-445; Coverage: 75%)
Gene names: FICD, HIP13, HYPE, UNQ3041/PRO9857
Sequence domains: Fic/DOC family
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand APC 8 x APC
Ligand MG 8 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 77.1Å b: 83.754Å c: 130.023Å
α: 89.92° β: 89.57° γ: 89.43°
R-values:
R R work R free
0.208 0.206 0.251
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Early Events in the Endoplasmic Reticulum Unfolded Protein Response.
Preissler et al. (2019)
4 more

2 mentions without citation

Fic and non-Fic AMPylases: protein AMPylation in metazoans.
Chatterjee et al. (2021)
1 more