› 4u1w

X-ray diffraction
3.25Å resolution

Full length GluA2-kainate-(R,R)-2b complex crystal form A

Released:
DOI: 10.2210/pdb4u1w/pdb
PDB entry 4u1w coloured by chain, front view.
PDB entry 4u1w coloured by chain, side view.
PDB entry 4u1w coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E
Cell 158 778-792 (2014)
PMID: 25109876

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 824 amino acids
Theoretical weight: 92.39 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand KAI 4 x KAI
Ligand NAG 4 x NAG
Ligand FWF 2 x FWF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 104.5Å b: 151.11Å c: 332.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.272 0.27 0.316
Expression system: Homo sapiens

Quick links

Citations

29 review citations

The Lysosome as a Regulatory Hub.
Perera et al. (2016)
28 more

6 mentions without citation

Emerging structural insights into the function of ionotropic glutamate receptors.
Karakas et al. (2015)
5 more