› 4u5t

X-ray diffraction
3.3Å resolution

Crystal Structure of VBP Leucine Zipper with Bound Arylstibonic Acid

Released:
DOI: 10.2210/pdb4u5t/pdb
PDB entry 4u5t coloured by chain, front view.
PDB entry 4u5t coloured by chain, side view.
PDB entry 4u5t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA.
Zhao J, Stagno JR, Varticovski L, Nimako E, Rishi V, McKinnon K, Akee R, Shoemaker RH, Ji X, Vinson C
Mol Pharmacol 82 814-23 (2012)
PMID: 22851716

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171236 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyrotroph embryonic factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 39 amino acids
Theoretical weight: 4.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q10587 (Residues: 257-295; Coverage: 13%)
Gene names: KIAA1655, TEF
Sequence domains: Basic region leucine zipper

Ligands and Environments

1 bound ligand:
Ligand 3CG 1 x 3CG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P61
Unit cell:
a: 68.84Å b: 68.84Å c: 77.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.262 0.26 0.278
Expression system: Not provided

Quick links

Citations

4 review citations

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.
Uversky et al. (2014)
3 more

3 mentions without citation

Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides.
Wang et al. (2021)
2 more