› 4u6g

X-ray diffraction
4.2Å resolution

Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide

Released:
DOI: 10.2210/pdb4u6g/pdb
PDB entry 4u6g coloured by chain, front view.
PDB entry 4u6g coloured by chain, side view.
PDB entry 4u6g coloured by chain, top view.
Source organisms:
Entry authors: Ofek G, Bird GH, Walensky LD, Kwong PD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207911 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
10E8 Fab Heavy Chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 236 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
10E8 Fab Light Chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 215 amino acids
Theoretical weight: 22.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Envelope glycoprotein Chains: C, P
Molecule details ›
Chains: C, P
Length: 17 amino acids
Theoretical weight: 2.19 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: I3VHW6 (Residues: 126-141; Coverage: 9%)
Gene name: env

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DIV 2 x DIV
Ligand MK8 2 x MK8

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 68.562Å b: 126.317Å c: 129.875Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.281
Expression systems:
  • Homo sapiens
  • Not provided

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