› 4u8a

X-ray diffraction
1.48Å resolution

Crystal structure of D(CGCGAATTCGCG)2 complexed with BPH-1503

Released:
DOI: 10.2210/pdb4u8a/pdb
PDB entry 4u8a coloured by chain, front view.
PDB entry 4u8a coloured by chain, side view.
PDB entry 4u8a coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Antibacterial drug leads: DNA and enzyme multitargeting.
Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E
J Med Chem 58 1215-27 (2015)
PMID: 25574764

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-118184 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand 3EZ 1 x 3EZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 25.175Å b: 40.144Å c: 65.633Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.266 0.322
Expression system: Not provided

Quick links

Citations

14 citation in other articles

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.
Stokes et al. (2017)
13 more

3 mentions without citation

Antibacterial drug leads: DNA and enzyme multitargeting.
Zhu et al. (2015)
2 more