› 4uc2

X-ray diffraction
2.4Å resolution

Crystal structure of translocator protein 18kDa (TSPO) from rhodobacter sphaeroides (A139T mutant) in P212121 space group

Released:
DOI: 10.2210/pdb4uc2/pdb
PDB entry 4uc2 coloured by chain, front view.
PDB entry 4uc2 coloured by chain, side view.
PDB entry 4uc2 coloured by chain, top view.
Source organism: Cereibacter sphaeroides
Primary publication:
Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism.
Li F, Liu J, Zheng Y, Garavito RM, Ferguson-Miller S
Science 347 555-8 (2015)
PMID: 25635101

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan-rich sensory protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 156 amino acids
Theoretical weight: 17.81 KDa
Source organism: Cereibacter sphaeroides
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9RFC8 (Residues: 2-157; Coverage: 99%)
Gene names: crtK, tspO
Sequence domains: TspO/MBR family

Ligands and Environments

2 bound ligands:
Ligand OLC 6 x OLC
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 39.083Å b: 95.837Å c: 105.827Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.236
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Leydig cells: formation, function, and regulation.
Zirkin et al. (2018)
32 more

9 mentions without citation

Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism.
Li et al. (2015)
8 more