› 4uc3

X-ray diffraction
2.5Å resolution

Translocator protein 18 kDa (TSPO) from Rhodobacter sphaeroides wild type

Released:
DOI: 10.2210/pdb4uc3/pdb
PDB entry 4uc3 coloured by chain, front view.
PDB entry 4uc3 coloured by chain, side view.
PDB entry 4uc3 coloured by chain, top view.
Source organism: Cereibacter sphaeroides
Primary publication:
Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism.
Li F, Liu J, Zheng Y, Garavito RM, Ferguson-Miller S
Science 347 555-8 (2015)
PMID: 25635101

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan-rich sensory protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 155 amino acids
Theoretical weight: 17.67 KDa
Source organism: Cereibacter sphaeroides
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9RFC8 (Residues: 3-157; Coverage: 98%)
Gene names: crtK, tspO
Sequence domains: TspO/MBR family

Ligands and Environments

2 bound ligands:
Ligand OLC 3 x OLC
Ligand YZY 1 x YZY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 49.1Å b: 61.706Å c: 52.676Å
α: 90° β: 112.53° γ: 90°
R-values:
R R work R free
0.22 0.218 0.278
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Leydig cells: formation, function, and regulation.
Zirkin et al. (2018)
32 more

11 mentions without citation

VDAC1 and the TSPO: Expression, Interactions, and Associated Functions in Health and Disease States.
Shoshan-Barmatz et al. (2019)
10 more