› 4uee

X-ray diffraction
2.27Å resolution

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH

Released:
DOI: 10.2210/pdb4uee/pdb
PDB entry 4uee coloured by chain, front view.
PDB entry 4uee coloured by chain, side view.
PDB entry 4uee coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gallego P, Covaleda G, Costenaro L, Devel L, Dive V, Aviles FX, Reverter D

Function and Biology Details

Reaction catalysed: 
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 34.7 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P15085 (Residues: 111-419; Coverage: 77%)
Gene names: CPA, CPA1
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases

Ligands and Environments

2 bound ligands:
Ligand LA9 2 x LA9
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 46.298Å b: 83.983Å c: 157.096Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.154 0.225
Expression system: Komagataella pastoris

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