4ufr

X-ray diffraction
2.2Å resolution

Structure of the ectodomain of LGR5 in complex with R-spondin-2 (Fu1Fu2)

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-130980 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leucine-rich repeat-containing G-protein coupled receptor 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 484 amino acids
Theoretical weight: 54.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75473 (Residues: 32-486, 563-565, 566-566; Coverage: 52%)
Gene names: GPR49, GPR67, LGR5
Sequence domains:
Structure domains: Ribonuclease Inhibitor
R-spondin-2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 120 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BFU0 (Residues: 39-144; Coverage: 48%)
Gene name: Rspo2
Sequence domains: Furin-like repeat, cysteine-rich
Structure domains: Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 205.148Å b: 59.777Å c: 112.21Å
α: 90° β: 99.51° γ: 90°
R-values:
R R work R free
0.209 0.208 0.262
Expression system: Homo sapiens