› 4usn

Electron Microscopy
8.8Å resolution

The structure of the immature HIV-1 capsid in intact virus particles at sub-nm resolution

Released:
DOI: 10.2210/pdb4usn/pdb
PDB entry 4usn coloured by chain, front view.
PDB entry 4usn coloured by chain, side view.
PDB entry 4usn coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution.
Schur FK, Hagen WJ, Rumlová M, Ruml T, Müller B, Kräusslich HG, Briggs JA
Nature 517 505-8 (2015)
PMID: 25363765
Related structures: EMD-2706

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo hexamer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retroviral nucleocapsid Gag protein p24 C-terminal domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 210 amino acids
Theoretical weight: 23.43 KDa
Source organism: Human immunodeficiency virus 1
UniProt:
  • Canonical: Q9IVM8 (Residues: 4-213; Coverage: 93%)
Gene name: gag
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8.8Å
Relevant EMDB volumes: EMD-2706

Quick links

Citations

47 review citations

HIV-1 assembly, release and maturation.
Freed EO. (2015)
46 more

21 mentions without citation

HIV-1 Maturation: Lessons Learned from Inhibitors.
Kleinpeter et al. (2020)
20 more