› 4uv6

X-ray diffraction
2.45Å resolution

Crystal structure of apical membrane antigen 1 from Plasmodium knowlesi

Released:
DOI: 10.2210/pdb4uv6/pdb
PDB entry 4uv6 coloured by chain, front view.
PDB entry 4uv6 coloured by chain, side view.
PDB entry 4uv6 coloured by chain, top view.
Source organism: Plasmodium knowlesi strain H
Primary publication:
Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody.
Vulliez-Le Normand B, Faber BW, Saul FA, van der Eijk M, Thomas AW, Singh B, Kocken CH, Bentley GA
PLoS One 10 e0123567 (2015)
PMID: 25886591

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104748 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apical membrane antigen 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 370 amino acids
Theoretical weight: 42.51 KDa
Source organism: Plasmodium knowlesi strain H
Expression system: Komagataella pastoris
UniProt:
  • Canonical: A0A384KGX8 (Residues: 43-387; Coverage: 61%)
Gene name: PKNH_0931500
Sequence domains: Apical membrane antigen 1
Structure domains: Hepatocyte Growth Factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 90.32Å b: 105.7Å c: 104.75Å
α: 90° β: 98.04° γ: 90°
R-values:
R R work R free
0.172 0.171 0.227
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Plasmodium knowlesi malaria: current research perspectives.
Amir et al. (2018)
1 more

3 mentions without citation

Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody.
Vulliez-Le Normand et al. (2015)
2 more