› 4uwa

Electron Microscopy
6.1Å resolution

Structure of the ryanodine receptor at resolution of 6.1 A in closed state

Released:
DOI: 10.2210/pdb4uwa/pdb
PDB entry 4uwa coloured by chain, front view.
PDB entry 4uwa coloured by chain, side view.
PDB entry 4uwa coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Architecture and conformational switch mechanism of the ryanodine receptor.
Efremov RG, Leitner A, Aebersold R, Raunser S
Nature 517 39-43 (2015)
PMID: 25470059
Related structures: EMD-2751

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 5037 amino acids
Theoretical weight: 473.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11716 (Residues: 1-2939; Coverage: 58%)
Gene name: RYR1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 6.1Å
Relevant EMDB volumes: EMD-2751

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Citations

70 review citations

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.
Bagur et al. (2017)
69 more

3 mentions without citation

Ca2+ Release Channels Join the 'Resolution Revolution'.
Zalk et al. (2017)
2 more