› 4uwe

Electron Microscopy
8.5Å resolution

Structure of the ryanodine receptor at resolution of 8.5 A in partially open state

Released:
DOI: 10.2210/pdb4uwe/pdb
PDB entry 4uwe coloured by chain, front view.
PDB entry 4uwe coloured by chain, side view.
PDB entry 4uwe coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Architecture and conformational switch mechanism of the ryanodine receptor.
Efremov RG, Leitner A, Aebersold R, Raunser S
Nature 517 39-43 (2015)
PMID: 25470059
Related structures: EMD-2752

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 5037 amino acids
Theoretical weight: 473.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11716 (Residues: 1-2939; Coverage: 58%)
Gene name: RYR1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8.5Å
Relevant EMDB volumes: EMD-2752

Quick links

Citations

70 review citations

Single-Particle Cryo-EM at Crystallographic Resolution.
Cheng Y. (2015)
69 more

2 mentions without citation

Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.
Ogawa et al. (2021)
1 more