› 4v0p

X-ray diffraction
2.07Å resolution

Crystal structure of the MAGE homology domain of human MAGE-A3

Released:
DOI: 10.2210/pdb4v0p/pdb
PDB entry 4v0p coloured by chain, front view.
PDB entry 4v0p coloured by chain, side view.
PDB entry 4v0p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Newman JA, Cooper CD, Roos AK, Aitkenhead H, Oppermann UC, Cho HJ, Osman R, Gileadi O
PLoS One 11 e0148762 (2016)
PMID: 26910052

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melanoma-associated antigen 3 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P43357 (Residues: 104-314; Coverage: 67%)
Gene names: MAGE3, MAGEA3
Sequence domains: MAGE homology domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6122
Unit cell:
a: 61.473Å b: 61.473Å c: 292.831Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases.
Lee et al. (2017)
3 more

7 mentions without citation

Emerging roles of the MAGE protein family in stress response pathways.
Florke Gee et al. (2020)
6 more